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William A Catterall Selected Research

Voltage-Gated Sodium Channels

1/2021Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome.
1/2019Hippocampal deletion of NaV1.1 channels in mice causes thermal seizures and cognitive deficit characteristic of Dravet Syndrome.
12/2018Fenestrations control resting-state block of a voltage-gated sodium channel.
4/2018Dravet Syndrome: A Sodium Channel Interneuronopathy.
1/2018Structural basis for gating pore current in periodic paralysis.
10/2017Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.
8/2015Dissecting the phenotypes of Dravet syndrome by gene deletion.
5/2015Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.
1/2015Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome.
7/2014Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.
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William A Catterall Research Topics

Disease

22Myoclonic Epilepsies (Myoclonic Encephalopathy)
01/2021 - 09/2006
18Epilepsy (Aura)
10/2021 - 01/2002
13Seizures (Absence Seizure)
11/2019 - 12/2002
7Paralysis (Palsy)
10/2021 - 03/2007
7Cardiac Arrhythmias (Arrythmia)
10/2019 - 01/2002
5Pain (Aches)
01/2021 - 01/2002
5Epileptic Syndromes
07/2014 - 06/2010
5Generalized Epilepsy with Febrile Seizures Plus
01/2014 - 11/2008
5Ataxia (Dyssynergia)
04/2011 - 03/2007
4Migraine Disorders (Migraine)
10/2021 - 03/2007
4Channelopathies
10/2021 - 03/2007
4Hypertension (High Blood Pressure)
10/2019 - 08/2006
3Autistic Disorder (Autism)
10/2021 - 09/2012
3Cognitive Dysfunction
11/2019 - 09/2012
3Angina Pectoris
10/2019 - 08/2006
3Cardiovascular Diseases (Cardiovascular Disease)
10/2019 - 10/2005
3Cardiomegaly (Heart Hypertrophy)
12/2016 - 04/2011
3Chronic Pain
07/2015 - 12/2006
2Febrile Seizures (Febrile Seizure)
01/2021 - 06/2010
2Drug Resistant Epilepsy
01/2019 - 04/2013
2Bipolar Disorder (Manic Depressive Psychosis)
01/2018 - 07/2015
2Heart Failure
12/2016 - 04/2011
2Ventricular Tachycardia
10/2012 - 07/2011
2Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic)
08/2010 - 12/2008
1Schizophrenia (Dementia Praecox)
01/2018
1Cerebellar Ataxia (Dysmetria)
01/2018
1Neurodevelopmental Disorders
01/2018
1Neuroblastoma
09/2017
1Inborn Genetic Diseases (Disease, Hereditary)
09/2017
1Cantu syndrome
01/2016
1Sleep Wake Disorders
05/2015
1Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions)
01/2014
1Sudden Death
11/2013
1Bradycardia
04/2013
1Sudden Unexpected Death in Epilepsy
04/2013
1Ischemia
01/2013
1Ventricular Premature Complexes (Premature Ventricular Contraction)
10/2012
1Body Weight (Weight, Body)
11/2011
1Dehydration (Water Stress)
07/2011
1Hypertrophy
04/2011
1Scorpion Stings
10/2010
1Familial Periodic Paralyses (Normokalemic Periodic Paralysis)
08/2010
1Brain Diseases (Brain Disorder)
03/2009

Drug/Important Bio-Agent (IBA)

19Voltage-Gated Sodium ChannelsIBA
01/2021 - 12/2007
16Sodium Channels (Sodium Channel)IBA
10/2021 - 12/2002
12SodiumIBA
10/2021 - 09/2006
7Calcium Channels (Calcium Channel)IBA
01/2020 - 11/2008
5Pharmaceutical PreparationsIBA
10/2019 - 01/2002
4Adrenergic Agents (Adrenergic Drugs)IBA
12/2016 - 04/2011
3Clonazepam (Rivotril)FDA LinkGeneric
01/2021 - 09/2012
3CannabidiolIBA
01/2021 - 10/2017
3CalciumIBA
10/2019 - 11/2008
3Sodium Channel BlockersIBA
04/2018 - 06/2010
3Arginine (L-Arginine)FDA Link
08/2014 - 03/2007
2Proteins (Proteins, Gene)FDA Link
01/2020 - 12/2016
2Drug CombinationsIBA
04/2018 - 06/2010
2CationsIBA
01/2018 - 08/2010
2PotassiumIBA
01/2018 - 12/2008
2DihydropyridinesIBA
01/2016 - 08/2006
2ParvalbuminsIBA
08/2015 - 07/2014
2Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
08/2015 - 07/2014
2Isoproterenol (Isoprenaline)FDA LinkGeneric
11/2013 - 07/2011
2GABA-A Receptors (GABA(A) Receptor)IBA
05/2013 - 09/2012
2Flurothyl (Flurotyl)IBA
11/2011 - 12/2007
2Ion Channels (Ion Channel)IBA
11/2008 - 03/2007
1BenzodiazepinesIBA
01/2021
1Diltiazem (Cardizem)FDA LinkGeneric
10/2019
1Molecular Probes (Molecular Probe)IBA
09/2017
1NeurotoxinsIBA
09/2017
1CalcineurinIBA
12/2016
1Casein Kinase II (Casein Kinase 2)IBA
12/2016
1Calcineurin InhibitorsIBA
12/2016
1Therapeutic UsesIBA
01/2016
1Adenosine Triphosphate (ATP)IBA
01/2016
1KATP ChannelsIBA
01/2016
1Amino AcidsFDA Link
08/2014
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2014
1gamma-Aminobutyric Acid (GABA)IBA
05/2013
1Tiagabine (Gabitril)FDA Link
05/2013
1GABA Uptake InhibitorsIBA
05/2013
1Scopolamine (Hyoscine)FDA Link
04/2013
1AtropineFDA LinkGeneric
04/2013
1Adrenergic Receptors (Adrenergic Receptor)IBA
01/2013
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
10/2012
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
10/2012
1Phosphatidylinositols (Phosphatidylinositol)IBA
10/2012
1Protein Isoforms (Isoforms)IBA
10/2012
1CatecholaminesIBA
10/2012
1Glucose (Dextrose)FDA LinkGeneric
11/2011
1Glutamic Acid (Glutamate)FDA Link
07/2011
1Scorpion Venoms (Scorpion Venom)IBA
10/2010
1GD3 ganglioside (GD(3))IBA
08/2010
1Guanidine (Guanidine Nitrate)FDA Link
08/2010
1Messenger RNA (mRNA)IBA
06/2010
1Protons (Proton)IBA
12/2008

Therapy/Procedure

8Therapeutics
01/2021 - 01/2002
1Local Anesthesia
07/2015
1Ketogenic Diet
11/2011
1Intraperitoneal Injections
07/2011
1Catheters
07/2011